Press Archive
- Charles Francis: Weakening eye surgery laws places WV patients in jeopardy
- Mark D. Mayle, MD - 2022 Secretariat Award Recipients
- Dr. Larry Schwab recognized with 2020 International Blindness Prevention Award
- Wow Moment with Joseph A. LoCasio | Bio-Tissue | #WowWednesdays
- WVU Today | Moore, Oppe named recipients of Heebink award for Distinguished Service
- Cornea Transplant Restores Young Boy’s Sight After Fishing Accident
- Keep your eyes healthy and safe in the workplace
- Glaucoma Awareness Month
- Ophthalmologists Say 90 Percent of Work-Related Eye Injuries Can be Avoided by Wearing Eye Protection
- Five Tips to Avoid Toy-Related Eye Injuries
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We read with great interest the recent paper by Kwon et al1 in which the authors examine the aqueous levels of cytokines in patients with diabetic eye disease, including angiopoietin-like 4 (ANGPTL4), a protein we and others have identified as an important vascular hyperpermeability factor in cancer.2 We were pleased to see the authors corroborate our recent study in which we first identified ANGPTL4 as an important player in the promotion of macular edema in patients with ischemic retinal disease, including diabetic macular edema.
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The article by Crama and Klevering (see p. 32) makes important observations about significant long-term complications of hydrogel episcleral implants (MIRAgel; MIRA, Inc., Waltham, MA) used as scleral buckles in 467 eyes. This is the largest series reported of the complications of MIRAgel implants and illustrates how these implants swell slowly, eventually creating orbital masses, extraocular motility disorders, buckle exposure, and intraocular complications. The enlargement of the MIRAgel scleral buckle increased progressively, so patients did not experience problems until 5 to 10 years after their retinal detachment repair.
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We read with interest the article by Mehta et al1 on vitreous evaluation. We were impressed and intrigued by the large number of vitreous samples evaluated by cytopathology from the 3 institutions. The authors described negative biopsy reports for malignancy from 5736 vitreous samples. The rationale for subjecting vitreous samples from therapeutic vitrectomies to cytopathology by Tufts Medical Center and Boston Medical Center begs further explanation, because most centers do not routinely practice vitreous sampling for vitrectomies related to vitreous hemorrhage and cases such as the removal of lens fragments, lens capsule, and internal limiting membrane.
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Small (p. 9) 等就引起北卡罗林纳黄斑营养不良 (North Carolina macular dystrophy [NCMD]) 致病基因变异进行研究。研究者发现了5种罕见变异, 每种都可以引起人类黄斑发育停滞。其中4种变异高度提示PRDM13参与黄斑发育过程; 虽然第5种变异病理生理机制不明, 但它可能与IRX1发育调节异常相关。本课题中, 研究者对人类视网膜细胞进行全基因组测序及基因表达分析。样本包括来自12个NCMD家族的41名受试者和261名非亲属对照受试个体。研究者发现本文报道的每种变异仅能通过3项基于PCR的测序反应被检测——另外, 通过一项针对NCMD的简单基因检测, 可同时提高对该病变的认知并增加新诊断病例数量。