We read with interest the article by Mehta et al1 on vitreous evaluation. We were impressed and intrigued by the large number of vitreous samples evaluated by cytopathology from the 3 institutions. The authors described negative biopsy reports for malignancy from 5736 vitreous samples. The rationale for subjecting vitreous samples from therapeutic vitrectomies to cytopathology by Tufts Medical Center and Boston Medical Center begs further explanation, because most centers do not routinely practice vitreous sampling for vitrectomies related to vitreous hemorrhage and cases such as the removal of lens fragments, lens capsule, and internal limiting membrane.
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