AAO Journal Archive
- Classification of Vitreous Seeds in Retinoblastoma
- Topical 5-Fluorouracil 1% as Primary Treatment for Ocular Surface Squamous Neoplasia
- Individualized Stabilization Criteria–Driven Ranibizumab versus Laser in Branch Retinal Vein Occlusion
- Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen
- Pseudodrusen and Incidence of Late Age-Related Macular Degeneration in Fellow Eyes in the Comparison of Age-Related Macular Degeneration Treatments Trials
- Pharmacotherapies for Retinal Detachment
- Can Automated Imaging for Optic Disc and Retinal Nerve Fiber Layer Analysis Aid Glaucoma Detection?
- Suture Colonization Rate in Adjustable Strabismus Surgery
- Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract
- Diagnostic Accuracy of Optical Coherence Tomography and Scanning Laser Tomography for Identifying Glaucoma in Myopic Eyes
- Details
The article by Crama and Klevering (see p. 32) makes important observations about significant long-term complications of hydrogel episcleral implants (MIRAgel; MIRA, Inc., Waltham, MA) used as scleral buckles in 467 eyes. This is the largest series reported of the complications of MIRAgel implants and illustrates how these implants swell slowly, eventually creating orbital masses, extraocular motility disorders, buckle exposure, and intraocular complications. The enlargement of the MIRAgel scleral buckle increased progressively, so patients did not experience problems until 5 to 10 years after their retinal detachment repair.
- Details
We read with interest the article by Mehta et al1 on vitreous evaluation. We were impressed and intrigued by the large number of vitreous samples evaluated by cytopathology from the 3 institutions. The authors described negative biopsy reports for malignancy from 5736 vitreous samples. The rationale for subjecting vitreous samples from therapeutic vitrectomies to cytopathology by Tufts Medical Center and Boston Medical Center begs further explanation, because most centers do not routinely practice vitreous sampling for vitrectomies related to vitreous hemorrhage and cases such as the removal of lens fragments, lens capsule, and internal limiting membrane.
- Details
Small (p. 9) 等就引起北卡罗林纳黄斑营养不良 (North Carolina macular dystrophy [NCMD]) 致病基因变异进行研究。研究者发现了5种罕见变异, 每种都可以引起人类黄斑发育停滞。其中4种变异高度提示PRDM13参与黄斑发育过程; 虽然第5种变异病理生理机制不明, 但它可能与IRX1发育调节异常相关。本课题中, 研究者对人类视网膜细胞进行全基因组测序及基因表达分析。样本包括来自12个NCMD家族的41名受试者和261名非亲属对照受试个体。研究者发现本文报道的每种变异仅能通过3项基于PCR的测序反应被检测——另外, 通过一项针对NCMD的简单基因检测, 可同时提高对该病变的认知并增加新诊断病例数量。
- Details
Small y otros (p. 9) se propusieron identificar las mutaciones que causan la distrofia macular de Carolina del Norte (NCMD). Identificaron 5 extrañas mutaciones, cada una de las cuales es capaz de detener el desarrollo de la mácula humana. Cuatro de dichas mutaciones implican la importante participación del gen PRDM13 en el desarrollo macular y, aunque sigue sin conocerse aún el mecanismo fisiopatológíco de la quinta mutación, es posible que se relacione con el desarrollo de disregulación del IRX1.
- Details
A 77-year-old man presented with painless, progressive, proptosis and diminution of vision in the right eye of 30 years duration. Examination of the right eye (OD) revealed (A) no light perception, proptosis with inferior displacement of the globe, a dilated and fixed pupil, and pallor of the optic disc. (B) Computed tomography of the orbit demonstrated an osteolytic lesion centered in the frontal process of zygomatic bone. On biopsy the lesion showed (C) epithelial cells in a cord-like arrangement with small, round, nuclei and abundant vacuolated cytoplasm.