AAO Journal Archive
- Classification of Vitreous Seeds in Retinoblastoma
- Topical 5-Fluorouracil 1% as Primary Treatment for Ocular Surface Squamous Neoplasia
- Individualized Stabilization Criteria–Driven Ranibizumab versus Laser in Branch Retinal Vein Occlusion
- Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen
- Pseudodrusen and Incidence of Late Age-Related Macular Degeneration in Fellow Eyes in the Comparison of Age-Related Macular Degeneration Treatments Trials
- Pharmacotherapies for Retinal Detachment
- Can Automated Imaging for Optic Disc and Retinal Nerve Fiber Layer Analysis Aid Glaucoma Detection?
- Suture Colonization Rate in Adjustable Strabismus Surgery
- Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract
- Diagnostic Accuracy of Optical Coherence Tomography and Scanning Laser Tomography for Identifying Glaucoma in Myopic Eyes
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I agree with the author about the need for more basic research on amblyopia; in fact, it is the subject of the concluding paragraph of my editorial. However, my task was to comment on the Pediatric Eye Disease Investigator Group (PEDIG) study of levodopa and its lack of utility in amblyopia treatment. I take it the author agrees with my comments, although the letter does not reflect this.
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We appreciate the invitation to comment on the correspondence by Sodhi and Montaner on the clinical significance of our study.1 Ma et al2 showed that angiopoietin-like 4 (ANGPTL4) plays a prominent role in promoting angiogenesis and vessel permeability observed in Kaposi sarcoma. Xin et al3 reported that ANGPTL4 was upregulated by hypoxia-inducible factor-1α in hypoxic inner retina in oxygen-induced retinopathy model. Because we could not analyze the expression of ANGPTL4 in the ischemic retina from live patients, we analyzed the aqueous levels of ANGPTL4 from controls and patients with diabetic retinopathy.
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Dr Hoyt raises important questions about the centuries old occlusion treatment for amblyopia. The scientific sequence for treating disorders is to determine their natural history and etiology and then to develop a treatment protocol. Animal experiments using occlusion did produce anatomic defects in the visual cortex. However, when Horton et al used cytochrome oxidase histochemistry to examine the ocular dominance columns in human amblyopia patients, defects in the lateral geniculate body were not found.
Read more: Re: Hoyt C.: What is next in amblyopia treatment? (Ophthalmology 2015;122:871-3)
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The relatively rapid and recent adoption of electronic health records (EHRs) in ophthalmology1,2 has been associated with the promise that the accumulation of large volumes of clinical data would facilitate quality improvement and help answer a variety of research questions. Given that EHRs are relatively new in most practices and that clinical data are inherently more complex than other fields that have been altered by the digital revolution, these proposed benefits have yet to be realized.3 The results reported by Shen et al4 in this issue of Ophthalmology (see p.
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We thank Agrawal and Siantar for comments on our recent paper.1 The main aim of our paper was to advocate appropriate handling of vitreous samples. These recommendations were possible on the strength of the large cohort obtained from 2 tertiary-level academic teaching hospitals (Boston Medical Center and Tufts Medical Center) where vitreous samples were not discarded based on the clinician's preference and where it is customary to send most surgically excised tissues for pathologic evaluation. This practice allowed for appreciation and documentation of the normal elements in a specimen (vitreous), which is becoming increasingly rare owing to nonsurgical options for retinal diseases like diabetic retinopathy (injection of anti-vascular endothelial growth factor).