Dr Hoyt raises important questions about the centuries old occlusion treatment for amblyopia. The scientific sequence for treating disorders is to determine their natural history and etiology and then to develop a treatment protocol. Animal experiments using occlusion did produce anatomic defects in the visual cortex. However, when Horton et al used cytochrome oxidase histochemistry to examine the ocular dominance columns in human amblyopia patients, defects in the lateral geniculate body were not found.
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