Press Archive
- Charles Francis: Weakening eye surgery laws places WV patients in jeopardy
- Mark D. Mayle, MD - 2022 Secretariat Award Recipients
- Dr. Larry Schwab recognized with 2020 International Blindness Prevention Award
- Wow Moment with Joseph A. LoCasio | Bio-Tissue | #WowWednesdays
- WVU Today | Moore, Oppe named recipients of Heebink award for Distinguished Service
- Cornea Transplant Restores Young Boy’s Sight After Fishing Accident
- Keep your eyes healthy and safe in the workplace
- Glaucoma Awareness Month
- Ophthalmologists Say 90 Percent of Work-Related Eye Injuries Can be Avoided by Wearing Eye Protection
- Five Tips to Avoid Toy-Related Eye Injuries
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This report by Chew et al1 claims to refute our analyses2,3 showing a relationship among zinc supplementation, genotype, and age-related macular degeneration (AMD) progression. The report includes inaccurate and misleading statements, which we address below.
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Watanabe (p. 2103) 等在轻度Fuchs’角膜营养不良患者中就角膜滴状赘疣严重程度对视觉质量的影响进行研究。他们发现即使在裂隙灯检查未见角膜水肿的患者, 角膜滴状赘疣仍对其视觉质量产生不良影响, 由滴状赘疣向前的眼内光散射将引起视觉障碍。该横断面研究包括14名Fuchs’角膜营养不良患者的23例眼, 患眼均未见明显水肿。研究人员评估滴状赘疣面积比例及其与矫正远视力 (corrected distance visual acuity, CDVA)、字母对比敏感度 (letter contrast sensitivity, LCS) 以及眼内散射光之间的相关性。结果显示滴状赘疣严重程度与以上3项视觉指标均呈负相关关系。此外, 散射光程度较重患者CDVA及LCS较差。
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We thank Dr Pearlman for his comments regarding the controversy of whether we need to conduct genetic testing prior to administering the Age-Related Eye Disease Study (AREDS) supplements or not. He expressed his concern regarding the following: (1) whether we did a “pooled” analysis of our “residual cohort”1 with that of the cohort of Awh et al,2 (2) whether there was comparability in the residual cohort with the cohort of Awh et al, and (3) whether this residual cohort was large enough and truly independent to provide us with clinically meaningful information.
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Watanabe et al (p. 2103) investigated the effect of corneal guttae severity on the quality of vision in patients with mild Fuchs’ corneal dystrophy. They found that corneal guttae—even without edema seen on slit-lamp examination—have a negative impact on patients’ quality of vision, and that intraocular forward light scatter caused by the guttae may result in visual disturbances. This cross-sectional study included 23 eyes of 14 patients who had Fuchs’ dystrophy but no evident edema. The researchers evaluated the area ratio of the guttae and correlated that with corrected distance visual acuity (CDVA), letter contrast sensitivity (LCS), and intraocular straylight.
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We agree with Dr Odaibo that small sample sizes in subgroups and data-derived biases are problematic in assessing the subgroup analysis conducted by Awh et al.1 The small sample size means that, at best, the conclusions of the subgroup analysis are useful for hypothesis development. The biases, inherent in data-derived analyses, make it even more important that there are replicate analyses before accepting the associations in the Awh et al analysis, as suggested by Dr Odaibo. The replicate analysis of the independent “residual cohort” provides no indication that the genotypes complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) have any influence on the response to treatment with Age-Related Eye Disease Study (AREDS) supplements (combination of antioxidants and zinc).