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In our randomized trial comparing part-time patching with observation for intermittent exotropia in children 12 to 35 months of age, we reported the incidence of deterioration of intermittent exotropia for each group over a 6-month period.1 We did not measure orbital parameters and we are therefore unable to comment on any association between intermittent exotropia and orbital anatomy. The potential effects of differences in orbital anatomy between patients, or potential effects of longitudinal changes in orbital anatomy, were minimized by our random allocation of treatment assignments in this study.
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We read with interest the article titled “Vitreomacular interface after anti-vascular endothelial growth factor injections in neovascular age-related macular degeneration” by Veloso et al.1 The investigators evaluated the incidence of posterior vitreous detachment (PVD) induced by intravitreal injections of anti-vascular endothelial growth factor agents in cases of neovascular age-related macular degeneration.
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We thank Khanduja et al for their interest in our manuscript.1 First, we wish to clarify that all patients in our study were followed for ≥3 months, with a mean follow-up period of 21.3 months (range, 3–59), and not over a period of 2–59 months as suggested in the correspondence.
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A 42-year-old woman with history of ovarian cancer after recent induction chemotherapy was referred for bilateral progressive vision loss of 4 months duration. On presentation, her visual acuity was 20/40 in both eyes. Funduscopic examination (Fig 1A) revealed bilateral nummular retinal pigment epithelial (RPE) clumping that with autofluorescence imaging (Fig 1B) appeared as islands of decreased autofluorescence surrounded by zones of increased autofluorescence signal in a giraffe-like pattern. The inverse was observed with fluorescein angiography (Fig 1C).
Read more: Giraffe Pattern of Bilateral Diffuse Uveal Melanocytic Proliferation
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Thinkers have long appreciated that the human eye is a remarkable product of natural engineering. The ability to resolve 1 minute of arc is amazing, but human perception goes beyond the optics to make sense of the inputs; the understanding of that integration is the study of neuro-ophthalmology. Neuro-ophthalmology melds 2 disciplines, neurology and ophthalmology, exploring the link between the eye and the brain. This link begins with the afferent input through the optic nerve, involves complex processing, and includes efferent output to control the pupil and eye movements.
Read more: The Foundation of Neuro-ophthalmology in the United States of America
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We wish to thank the authors for their letter and also thank them for reading our paper.1 Volume rendering has been used in representation of both computed tomography and magnetic resonance imaging for more than 3 decades. Thus, the techniques used in our paper are not new. We suggest reading the quoted sentence in the context of the paragraph in which it was embedded. We stated that the previous paper that we published concerning MacTel 2 used en face imaging2 and there were potential limitations when using this technique.