AAO Journal Archive
- Classification of Vitreous Seeds in Retinoblastoma
- Topical 5-Fluorouracil 1% as Primary Treatment for Ocular Surface Squamous Neoplasia
- Individualized Stabilization Criteria–Driven Ranibizumab versus Laser in Branch Retinal Vein Occlusion
- Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen
- Pseudodrusen and Incidence of Late Age-Related Macular Degeneration in Fellow Eyes in the Comparison of Age-Related Macular Degeneration Treatments Trials
- Pharmacotherapies for Retinal Detachment
- Can Automated Imaging for Optic Disc and Retinal Nerve Fiber Layer Analysis Aid Glaucoma Detection?
- Suture Colonization Rate in Adjustable Strabismus Surgery
- Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract
- Diagnostic Accuracy of Optical Coherence Tomography and Scanning Laser Tomography for Identifying Glaucoma in Myopic Eyes
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Liu et al (p. 2243) used spectral-domain optical coherence tomography (SD OCT) to examine whether progressive thinning of the retinal nerve fiber layer (RNFL) occurs in the contralateral eye of glaucoma patients with unilateral progression that was originally diagnosed via visual fields or optic disc photography. They noted RNFL loss in the fellow eyes of a substantial number of patients. This prospective longitudinal cohort study involved 346 eyes of 173 patients (118 eyes with glaucoma and 228 eyes with suspect glaucoma at baseline).
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In their review, Yeh et al1 thoroughly assessed the available evidence regarding the safety and efficacy of therapies for macular edema (ME) associated with central retinal vein occlusion (CRVO). Of the treatments evaluated, anti-vascular endothelial grow factor (VEGF) pharmacotherapy was the most common intervention. The authors conducted an excellent comprehensive presentation and discussion of the Cruise, Copernicus, Galileo, and Swedish trials, providing level 1 evidence supporting the use of intravitreal injections with ranibizumab (Lucentis, Genentech, Inc., South San Francisco, CA), aflibercept (IVA; Eylea, Regeneron Pharmaceuticals, Inc., Tarrytown, NY), and bevacizumab (Avastin, Genentech, Inc., San Francisco, CA) in patients with ME after CRVO.
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Ophthalmic Technology Assessments (OTAs) have been a regular feature of Ophthalmology for more than 25 years. This month we publish what I imagine will be one of our most provocative OTAs, “Topical Nonsteroidal Anti-Inflammatory Drugs and Cataract Surgery” (see p. 2159). Therefore, as current Chair of the OTA Committee, I thought it would be timely to review the history of OTAs and the process by which they arise. Flora Lum, MD, Vice President, Quality and Data Science, at the American Academy of Ophthalmology (AAO), and Doris Mizuiri, Editorial/Production Coordinator with the AAO were instrumental in providing me with much of the background material.
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The recent Ebola virus disease (EVD) epidemic in West Africa has captured the world's attention. Ebola virus disease is a multisystem hemorrhagic fever with remarkably high mortality. Patients typically present with high fever and flu-like symptoms, progressing to diarrhea, vomiting, and disseminated hemorrhage with multisystem organ failure. Overall mortality is greater than 40%, with most patients dying within 1 month of contracting the virus. As of August 2015, there have been more than 27 000 reported cases worldwide resulting in more than 11 000 deaths, with more than 10 000 of these cases occurring during the 2014 to 2015 epidemic.
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We read with interest the article titled “Threat to fixation at diagnosis and lifetime risk of visual impairment in open-angle glaucoma” by Peters et al.1 In a retrospective study, they evaluated the association between threat to fixation (TTF) at diagnosis and low vision and blindness in a group of glaucoma patients with whom they followed up until death. They found TTF was not an independent risk factor for developing glaucoma blindness or low vision when the disease severity stage (expressed in terms of mean deviation) at the time of diagnosis was accounted for.