AAO Journal Archive
- Classification of Vitreous Seeds in Retinoblastoma
- Topical 5-Fluorouracil 1% as Primary Treatment for Ocular Surface Squamous Neoplasia
- Individualized Stabilization Criteria–Driven Ranibizumab versus Laser in Branch Retinal Vein Occlusion
- Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen
- Pseudodrusen and Incidence of Late Age-Related Macular Degeneration in Fellow Eyes in the Comparison of Age-Related Macular Degeneration Treatments Trials
- Pharmacotherapies for Retinal Detachment
- Can Automated Imaging for Optic Disc and Retinal Nerve Fiber Layer Analysis Aid Glaucoma Detection?
- Suture Colonization Rate in Adjustable Strabismus Surgery
- Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract
- Diagnostic Accuracy of Optical Coherence Tomography and Scanning Laser Tomography for Identifying Glaucoma in Myopic Eyes
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We thank Khanduja et al for their interest in our manuscript.1 First, we wish to clarify that all patients in our study were followed for ≥3 months, with a mean follow-up period of 21.3 months (range, 3–59), and not over a period of 2–59 months as suggested in the correspondence.
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A 42-year-old woman with history of ovarian cancer after recent induction chemotherapy was referred for bilateral progressive vision loss of 4 months duration. On presentation, her visual acuity was 20/40 in both eyes. Funduscopic examination (Fig 1A) revealed bilateral nummular retinal pigment epithelial (RPE) clumping that with autofluorescence imaging (Fig 1B) appeared as islands of decreased autofluorescence surrounded by zones of increased autofluorescence signal in a giraffe-like pattern. The inverse was observed with fluorescein angiography (Fig 1C).
Read more: Giraffe Pattern of Bilateral Diffuse Uveal Melanocytic Proliferation
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Thinkers have long appreciated that the human eye is a remarkable product of natural engineering. The ability to resolve 1 minute of arc is amazing, but human perception goes beyond the optics to make sense of the inputs; the understanding of that integration is the study of neuro-ophthalmology. Neuro-ophthalmology melds 2 disciplines, neurology and ophthalmology, exploring the link between the eye and the brain. This link begins with the afferent input through the optic nerve, involves complex processing, and includes efferent output to control the pupil and eye movements.
Read more: The Foundation of Neuro-ophthalmology in the United States of America
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We wish to thank the authors for their letter and also thank them for reading our paper.1 Volume rendering has been used in representation of both computed tomography and magnetic resonance imaging for more than 3 decades. Thus, the techniques used in our paper are not new. We suggest reading the quoted sentence in the context of the paragraph in which it was embedded. We stated that the previous paper that we published concerning MacTel 2 used en face imaging2 and there were potential limitations when using this technique.
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In their editorial, Brodsky and Jung1 describe neurophysiologic mechanisms for the development of intermittent exotropia. They state that “prolonged patching causes it (exotropia) to become manifest.”1