Intraocular lymphomas (i-OL) are rare and aggressive subsets of primary cerebral tumors. Little is known about the pathogenesis. This is explained by the scarcity of patients and the tiny amount of ocular fluid sampled for biological analyses. In most cases, i-OL is misdiagnosed because its clinical features can mimic other ocular conditions. To date, no independent biological tool is able to firmly diagnose i-OL; the combination of cytologic examination, immunochemistry, flow cytometry, and molecular analysis is required.
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